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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin, alpha1

Anti -Integrin, alpha1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IC N
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. Alpha1 associates with beta1, and the resulting heterodimeric cell-surface receptor recognizes collagen and laminin. The inserted von Willebrand factor type I domain in the alpha1 subunit is thought to be involved in collagen binding.
Catalog #I7661-30
ApplicationsSuitable for use in Immunocytochemistry. Other applications have not been tested.
Recommended DilutionsImmunocytochemistry: 15ug/ml shows positive immunostaining for integrin a1 (human) in HeLa cells and MRC-5 cells fixed with 95% ethanol/ 5% acetic acid and permeabilized with 8% BSA.
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1904-06F: IgG, H&L (FITC) (X-Adsorbed) Pab Gt xMo
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No0.T.63
HostMouse
SourceHuman
Concentration~0.4mg/ml
FormSupplied as liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride.
PurityPurified by Protein A affinity chromatography
ImmunogenPurified human Integrin alpha 1.
SpecificityRecognizes human integrin alpha 1
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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