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You are here:Home » Antibodies » Abs to Vitronectin » Anti -Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)

Anti -Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
In cell matrix adhesions, clustered integrins (each made up of a noncovalently linked alpha and beta subunit) bind to endothelium cell matrix (ECM) components via their globular head domains. They connect to the actin cytoskeleton via adaptor proteins that bind their short cytoplasmic tails. Cell matrix adhesions also act as signalling units by their capacity to organize the actin cytoskeleton and to accumulate various signalling intermediates. Integrin mediated adhesion regulates the actions of Rho-GTPases, which in turn affect cell-cell adhesion. The converse process can also take place: the activity of Rho-GTPases can be modulated by cadherins in adherens junctions. Besides mediating adhesion to ECM components, integrins participate in the assembly of an ECM. Alpha-V/beta-3 integrin is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
Catalog #I7661-35H
ApplicationsSuitable for use in Flow Cytometry and Immunoassays.. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityFor long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9G192
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
PurityPurified.
ImmunogenHuman Integrin, alphaV, beta3.
SpecificityRecognizes human alpha-V/beta-3 integrin present on human endothelium cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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