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You are here:Home » Antibodies » Antibodies-Integrin » Anti -Integrin alpha8

Anti -Integrin alpha8


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IC FC
Integrin alpha8 is a 170-200kD member of the integrin family of adhesion molecules. It forms an exclusive noncovalent heterodimer with integrin beta-1. Alpha-8/beta-1 romotes both cell adhesion and survival and is known to bind to fibronectin, the latency-associated peptide in latent TGF-beta 1 and nephronectin. Mouse integrin alpha-8 is a 1025aa type I transmembrane glycoprotein. It contains a 969aa extracellular region (aa38-1006) and a 29aa cytoplasmic domain. One isoform may exist that shows a truncation after Ala675 of the precursor. In the ECD, mouse Integrin alpha8 shares 96% and 90% aa sequence identity with rat and human Integrin alpha-8 protein, respectively.
Catalog #I7661-36V
ApplicationsSuitable for use in Western Blot, Immunocytochemistry, Flow Cytometry and Direct ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 0.1ug/ml
Immunocytochemistry: 5-15ug/ml used to detect Integrin alpha8 in immersion fixed 4T1 mouse mammary carcinoma cells.
Flow Cytometry: 2.5ug labels 10e6 4T1 mouse mammary carcinoma cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
Concentration~0.2mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 500ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to Phe38-Phe1007 from mouse Integrin alpha8, expressed in CHO cells (NP_001001309).
SpecificityRecognizes mouse Integrin alpha8. Shows <1% crossreactivity with recombinant human and mouse Integrin alpha5 and recombinant human and mouse Integrin alphaV in direct ELISA and Western Blot. Species Sequence Homology: rat (96%), human (90%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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