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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin alphaV, beta3 (FITC)

Anti -Integrin alphaV, beta3 (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IH IF
The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (3). Due to its involvement in angiogenesis, the integrin aVb3 receptor is one of the most intensely studied of the integrin receptors.
Catalog #I7661-37E2
ApplicationsSuitable for use in Immunoprecipitation, Immunofluorescence and Inhibition of adhesion. Not suitable for Immunohistochemical staining of paraffin-embedded tissue sections. Other applications have not been tested.
Recommended Dilution:
Inhibition of adhesion of cells to vitronectin coated surfaces: 10-25ug/ml
Immunohistochemistry/Immunofluorescence: Frozen
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q880
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS pH 7.6, 0.1% sodium azide, 15mg/ml BSA, before the addition of glycerol to 40%. Labeled with FITC.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified adhesion receptor from the human melanoma cell line M21.
SpecificityRecognizes the human vitronectin receptor aVb3 complex, an RGD-directed adhesion receptor. Species Crossreactivity: bovine, chick, monkey, porcine, canine, rabbit and avian. Not reactive with rat tissue.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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