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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin alphaV, beta3

Anti -Integrin alphaV, beta3

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IH IF
The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. (Cancer and Metastasis Reviews 1991. 10:3). Due to its involvement in angiogenesis, the integrin aVb3 receptor is one of the most intensely studied of the integrin receptors.
Catalog #I7661-37E4
ApplicationsSuitable for use in Immunoprecipitation, Immunoflourescence, Immunohistochemistry and Inhibition. Not effective for immunohistochemical staining of paraffin-embedded tissue sections. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry/Immunofluorescence: 10ug/ml for staining of bFGF-treated 6um cryosections of chick chorioallantoic membrane fixed with acetone.
Inhibition: 10-25ug/ml adheres cells to vitronectin coated surfaces.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q880
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.02M PBS, pH 7.6, 0.1% sodium azide.
PurityPurified by Protein A Sepharose chromatography
ImmunogenIntegrin alphaV, beta3 from human placenta.
SpecificityRecognizes human vitronectin receptor aVb3 complex, an RGD-directed adhesion receptor. Species Crossreactivity: bovine, chick, monkey, porcine, canine, rabbit and avian. Not reactive with rat tissue.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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