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You are here:Home » Antibodies » Antibodies-Vitronectin » Anti -Integrin alphaV beta3 (Integrin alpha V, Integrin alpha-V, ITGAV, Integrin beta 3 (Platelet Glycoprotein IIIa, Antigen CD61), Integrin beta-3, ITGB3, CD51, CD51 Antigen, CD61, GP3A, GPIIIa, Msk8, Platelet Membrane Glycoprotein IIIa, Vitronectin Receptor a

Anti -Integrin alphaV beta3 (Integrin alpha V, Integrin alpha-V, ITGAV, Integrin beta 3
(Platelet Glycoprotein IIIa, Antigen CD61), Integrin beta-3, ITGB3, CD51, CD51 Antigen,
CD61, GP3A, GPIIIa, Msk8, Platelet Membrane Glycoprotein IIIa, Vitronectin Receptor a

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E IP FC
In cell matrix adhesions, clustered integrins (each made up of a noncovalently linked alpha and beta subunit) bind to endothelium cell matrix (ECM) components via their globular head domains. They connect to the actin cytoskeleton via adaptor proteins that bind their short cytoplasmic tails. Cell matrix adhesions also act as signalling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin mediated adhesion regulates the actions of Rho-GTPases, which in turn affect cell-cell adhesion. The converse process can also take place: the activity of Rho-GTPases can be modulated by cadherins in adherens junctions. Besides mediating adhesion to ECM components, integrins participate in the assembly of an ECM. Alpha-V/beta-3 integrin is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
Catalog #I7661-37G
ApplicationsSuitable for use in ELISA, Flow Cytometry and Immunoprecipitation. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoBV3
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified
SpecificityRecognizes human Integrin alphaV beta3 present on human endothelium cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDKFZp686A08142, Integrin alpha-V Heavy Chain, Integrin alpha-V Light Chain, Platelet glycoprotein IIIa, RGD-dependent Vitronectin Receptor


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