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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin alphaV, beta5

Anti -Integrin alphaV, beta5

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IP IH IC FC
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Catalog #I7661-37Q
ApplicationsSuitable for use in the inhibition of attachment of HT29 cells to vitronectin, Inhibition of attachment of carcinoma and melanoma cells to vitronectin, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation, Flow Cytometry and ELISA. Other applications not tested.
Recommended DilutionsInhibition of attachment of HT29 cells to vitronectin: > 1:1000
Immunocytochemistry (acetone fixed only): 1:1500 (human carcinomas, normal epithelium and keratinocytes)
Immunohistochemistry: Acetone or paraformaldehyde fixed tissues.
Optimal dilution to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q1009
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman UCLA P3 cells (lung carcinoma)
SpecificityRecognizes human Integrin aVb5. Species Crossreactivity: chicken
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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