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Specifications

Clone Host Grade Applications Polyclonal Goat Affinity Purified E B

ITGA11 is a 155-160kD member of the integrin a chain family of molecules. It preferentially forms a cell surface heterodimer with b1 integrin. In particular, it is further classified as a collagen-binding group member, showing a preference for binding to collagen I and II. ITGA11 is expressed by embryonic mesenchymal cells in and around areas that incorporate, or utilize collagen during development. In adult tissue, fibroblasts express ITGA11, and collagen:ITGA11 interaction likely contributes to wound contraction and closure. Mature human ITGA11 is an 1167aa type I transmembrane glycoprotein. It contains a large 1120aa extracellular domain (ECD) (aa 23-1142) plus a short 24aa cytoplasmic region. The ECD shows 7 x 60aa FG-Gap repeats that generate b propellers (aa 24-650) with an intervening I domain that binds collagen (aa154-345). Over aa23-1142, human ITGA11 shares 90% aa identity with mouse ITGA11.
Catalog #	I7661-37U
Applications	Suitable for use in Direct ELISA, Western Blot. Other applications not tested.
Recommended Dilution	Direct ELISA: 0.5-1ug/ml. The detection limit is ~0.5ng/lane
	Western Blot: 1ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Source	Human
Concentration	~0.2mg/ml
Form	Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Recombinant corresponding to human Integrin a11 expressed in CHO cells (NP_001004439).
Specificity	Recognizes human Integrin a11 extracellular domain. Species sequence homology
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.