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Specifications

Clone Host Grade Applications Polyclonal Sheep Affinity Purified B IC

Integrin a11 ( ITGA11) is a 155-160kD member of the integrin alpha chain family of molecules. It preferentially forms a cell surface heterodimer with b1 Integrin. In particular, it is further classified as a collagen-binding group member, showing a preference for binding to collagen I and II, plus group A Streptococcal Scl1 protein. ITGA11 is expressed by embryonic mesenchymal cells in areas that incorporate collagen during development. In adult tissue, fibroblasts express ITGA11, and a collagen:ITGA11 interaction likely contributes to the formation of myofibroblasts. Mature mouse ITGA11 is an 1166aa type I transmembrane glycoprotein. It contains a large 1119aa extracellular domain (ECD) aa23-1141 plus a short 24aa cytoplasmic region. The ECD shows 7x60aa FG-Gap repeats that generate b-propellers aa24-650 with an intervening I domain that binds collagen aa164-345. There is one potential splice variant that shows an eight aa substitution for aa89-119 coupled to a seven aa insertion after Gly690. Over aa23-1141, mouse ITGA11 shares 95-90aa identity with rat and human ITGA11, respectively.
Catalog #	I7661-37U1
Applications	Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution	Western Blot: 1ug/ml
	Immunocytochemistry: 5-15ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Sheep
Source	Mouse
Concentration	Not determined
Form	Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Recombinant corresponding to aa19-1141 from mouse Integrin a11 expressed in CHO cells (P61622).
Specificity	Recognizes mouse Integrin a11. Species sequence homology: Recombinant human (Integrin a11 (2%), Integrin a2 and Integrin a10 (5% ).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.