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You are here:Home » Antibodies » Antibodies-Integrin » Anti -Integrin alpha 11

Anti -Integrin alpha 11


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B IC
Integrin a11 ( ITGA11) is a 155-160kD member of the integrin alpha chain family of molecules. It preferentially forms a cell surface heterodimer with b1 Integrin. In particular, it is further classified as a collagen-binding group member, showing a preference for binding to collagen I and II, plus group A Streptococcal Scl1 protein. ITGA11 is expressed by embryonic mesenchymal cells in areas that incorporate collagen during development. In adult tissue, fibroblasts express ITGA11, and a collagen:ITGA11 interaction likely contributes to the formation of myofibroblasts. Mature mouse ITGA11 is an 1166aa type I transmembrane glycoprotein. It contains a large 1119aa extracellular domain (ECD) aa23-1141 plus a short 24aa cytoplasmic region. The ECD shows 7x60aa FG-Gap repeats that generate b-propellers aa24-650 with an intervening I domain that binds collagen aa164-345. There is one potential splice variant that shows an eight aa substitution for aa89-119 coupled to a seven aa insertion after Gly690. Over aa23-1141, mouse ITGA11 shares 95-90aa identity with rat and human ITGA11, respectively.
Catalog #I7661-37U1
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunocytochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa19-1141 from mouse Integrin a11 expressed in CHO cells (P61622).
SpecificityRecognizes mouse Integrin a11. Species sequence homology: Recombinant human (Integrin a11 (2%), Integrin a2 and Integrin a10 (5% ).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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