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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin alphaV, beta6

Anti -Integrin alphaV, beta6

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH IC FC
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
Catalog #I7661-37X
ApplicationsSuitable for use in Immunohistochemistry, Flow Cytometry and Immunocytochemistry. Not recommended for Western Blot or Immunoprecipitation. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry (Acetone fixation): Effective for human tissue, especially in circumstances where up-regulation of the receptor is being evaluated. Not suitable for use on formalin-fixed or paraffin-embedded tissues. May not detect the low-level basal expression of Integrin alphaV, beta6 in epithelia of healthy adults.
Immunocytochemistry: Effective for F6, HT-29, H441 cell lines. (Other cell lines not tested).
Flow Cytometry: Effective for detection of human and monkey Integrin alphaV, beta6.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q872
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS. No preservatives added.
PurityPurified
ImmunogenRecombinant secreted human Integrin alphaV, beta6.
SpecificityRecognizes human Integrin alphaV, beta6. Does not react with the alphaV subunit or any other aV integrins. It is not known if the epitope recognized by I7661-37X is localized within the alphaV, beta6 heterodimer or within the beta6 subunit only. Species Crossreactivity: monkey
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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