Anti -Integrin, beta1 (CD29, Very Late Antigen, VLAb1, Platelet gplla, ITGB1, Fibrinogen
Receptor beta Subunit, FNRB, Integrin VLA4 Subunit beta, MDF2, MSK12, Very Late Activation
Protein beta Polypeptide, VLAB, VLAbeta)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IH FC |
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| The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and a beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family is based upon the pairing abilities of the individual alpha and beta subunits. Adhesion results in integrin aggregation into structures called focal adhesion plaques, which form the link between the extracellular space and the intracellular cytoskeleton. Signaling from focal adhesions is initiated by the kinases FAK, Pyk2 and ILK. Phosphorylation and cleavage of integrins result in modifications of cell adhesion, permitting physiological processes such as migration, vascular proliferation, and wound repair. | | | Integrin beta 1, also known as CD29, is a transmembrane glycoprotein that forms complexes with many integrin alpha subunits, (1 – 11), to form functional receptors that bind to specific extracellular matrix proteins. | | | Catalog # | I7661-38N2 | | Applications | Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:70 | | Western Blot: 1:500 | | Immunohistochemistry (paraffin): 1:250-500 | | Optimal dilutions to be determined by the researcher. | | Positive Control | U937 cell lysate. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9i43 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in Tris-Glycine, pH 7.4, 0.18M sodium chloride, 0.25% sodium azide, 0.25mM EDTA, 25 mM citric acid, 0.5% BSA, 40% glycerol. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to the residue near the C-terminal of human Integrin beta1. Cellular Localization: Cell membrane; Single-pass type I membrane protein. Melanosome. | | Specificity | Recognizes human Integrin, beta1. Species Crossreactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Integrin, beta1 (CD29, Very Late Antigen, VLAb1, Platelet gplla, ITGB1, Fibrinogen Receptor beta Subunit, FNRB, Integrin VLA4 Subunit beta, MDF2, MSK12, Very Late Activation Protein beta Polypeptide, VLAB, VLAbeta) |
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