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You are here:Home » Antibodies » Abs to Integrin » Anti -ITGB1 (Integrin beta-1, Fibronectin Receptor Subunit beta, Integrin VLA-4 Subunit beta, CD29, MSK12, MDF2, FNRB)

Anti -ITGB1 (Integrin beta-1, Fibronectin Receptor Subunit beta, Integrin VLA-4 Subunit
beta, CD29, MSK12, MDF2, FNRB)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Integrin B1 also known as integrin VLA-4 beta chain, fibronectin receptor beta chain, and CD29) is a 130kD integrin beta chain containing VWFA-like domains. Five isoforms have been reported (B1A-1D, 1C-2). This Type I membrane protein is a subunit of the heterodimeric receptor for laminin, fibronectin, collagen, fibrinogen, VCAM1, cytotactin, osteopontin, epiligrin, thrombospondin, and vitronectin. Signal transduction through the integrins affects embryogenesis, hemostasis, tissue repair, immune response, and metastatic spread of tumor cells. Integrin B1 can be upregulated by LPS with soluble CD14 and TNF-a; downregulation of integrin B1 by a-melanocyte stimulating hormone and progesterone. Integrin B1 is modified by phosphorylation and glycosylation. Integrin B1 partners with integrin alpha subunits av, and a1 through a1.1.
Catalog #I7661-38T1
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 10ug/ml requires Hier using Citrate Buffer, pH 6.0
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone NoK2D5
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to human CD29 aa34-141, expressed in E. coli.
SpecificityRecognizes human CD29.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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