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You are here:Home » Antibodies » Abs to Integrin » Anti -ITGB1BP1 (ICAP1, Integrin beta-1-binding Protein 1, Integrin Cytoplasmic Domain-associated Protein 1, ICAP-1)

Anti -ITGB1BP1 (ICAP1, Integrin beta-1-binding Protein 1, Integrin Cytoplasmic
Domain-associated Protein 1, ICAP-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
ITGB1BP1 (Integrin beta 1 binding protein 1) binds to the beta 1 integrin cytoplasmic domain and negatively regulates its function in vitro. It may play a role in the recruitment of beta 1 integrins to the focal contacts during integrin-dependent cell adhesion. ITGB1BP1 shuttles between the nucleus and cytoplasm in a beta 1 integrin-dependent manner. It may act as a messenger that relays information from sites of integrin-dependent cell adhesion to the nucleus for controlling gene expression and cell proliferation. There are two alternatively spliced isoforms of ITGB1BP1. The shorter isoform does not interact with the beta 1 integrin cytoplasmic domain.
Catalog #I7661-38X
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa92-105 of human ITGB1BP1 (KLH).
SpecificityRecognizes human ITGB1BP1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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