Anti -Integrin, beta1 (Integrin beta-1, ITGB1, CD29, Fibronectin Receptor Subunit beta,
FNRB, GPIIA, MDF2, MSK12, VLA-4 Subunit beta, VLA-BETA, VLAB)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B IP FC |
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| Integrin beta 1 is a 130kD transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. | | | Catalog # | I7661-39A7 | | Applications | Suitable for use in ELISA, Flow Cytometry, Western Blot, Immunoprecipitation and Purification. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:50 | | Flow Cytometry: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | BV7 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA. | | Purity | Purified | | Specificity | Recognizes human b1-integrin chain present on tumor cells. Active on HT-29 colon carcicoma cells and on HCCP-2998 tumor cells and binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC-1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Integrin, beta 1 (Fibronectin Receptor, beta Polypeptide, Antigen CD29 Includes MDF2, MSK12) |
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Download Specifications for Anti -Integrin, beta1 (Integrin beta-1, ITGB1, CD29, Fibronectin Receptor Subunit beta, FNRB, GPIIA, MDF2, MSK12, VLA-4 Subunit beta, VLA-BETA, VLAB) |
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