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You are here:Home » Antibodies » Antibodies-Integrin » Anti -Integrin beta2 (Cell Surface Adhesion Glycoproteins LFA-1/CR3/p150,95 Subunit beta, Complement Receptor C3 Subunit beta, ITGB2, MFI7)

Anti -Integrin beta2 (Cell Surface Adhesion Glycoproteins LFA-1/CR3/p150,95 Subunit beta,
Complement Receptor C3 Subunit beta, ITGB2, MFI7)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The 3 alpha integrin chains associated individually with the beta-2 chain as a heterodimer have gene designations of ITGAL, ITGAM, and ITGAX, and leukocyte antigen designations of CD11A, CD11B, and CD11C, respectively.The expression of CD18 was increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 211.The ITGB2 gene spans approximately 40 kb and contains 16 exons and all exon/intron boundaries conform to the GT/AG splicing consensus. Furthermore,ITGB2 was constitutively clustered. Although it was expressed on the cell surface at normal levels and was capable of function following extracellular stimulation, it could not be activated via the "inside-out" signaling pathways.
Catalog #I7661-41B
ApplicationsSuitable for use in Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot:1-2ug/ml
Immunohistochemistry (paraffin):1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide mapping at the N-terminal of human Integrin beta2,different from the related mouse sequence by 5aa.
SpecificityRecognizes human Integrin beta2. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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