Anti -Integrin, beta 3 (ITGB3, CD61, GP3A, GPIIIa, HPA-1, NAIT, Platelet Fibrinogen
Receptor beta Subunit, Platelet Glycoprotein IIIa, Platelet Membrane Glycoprotein IIIa)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| CD61, a 105kD membrane glycoprotein, is a member of Integrin family expressed on megakaryocytes, platelets and their precursor cells. It is a beta3-integrin subunit consisting of an N-terminal signal peptide, a transmembrane domain and a cysteine-rich cytoplasmic domain. CD61 is a functional subunit of platelet integrin GPIIb:IIIa receptor complex, fibronectin receptor and Vitronectin receptor. It mediates platelet aggregation, platelet spreading, clot retraction, microvesiculation, and hemostasis and also functions as a receptor for fibrinogen, fibronectin, Von Willebrand factor, Osteopontin and Vitronectin. | | | Catalog # | I7661-42F2 | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human bone marrow | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E232 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Supernatant | | Immunogen | PHA-stimulated human mononuclear cells. Cellular Localization: Cell membrane. | | Specificity | Recognizes human CD61. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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