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You are here:Home » Antibodies » Abs to Integrin » Anti -ITGB3, phosphorylated (Tyr773) (Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, CD61, GP3A)

Anti -ITGB3, phosphorylated (Tyr773) (Integrin beta-3, Platelet Membrane Glycoprotein
IIIa, GPIIIa, CD61, GP3A)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. AlphaIIbeta3 and alphaVbeta3 are the two beta3 containing integrins, which are prominently expressed in hematopoitic cells and angiogenic endothelic cells and perform adhesive functions in hemostasis, wound healing and angiogenesis. Integrin b3 localizes in the 17q21.32 region of chromosome. Alternate splicing of integrin b3 produces three isoforms, Beta-3A, Beta-3B and Beta-3C. Isoform beta-3A is specifically expressed in osteoblast cells and isoform beta-3C is specifically expressed in prostate and testis. Defects in integrin b3 cause Glanzmann thrombasthenia (GT).
Catalog #I7661-42K1
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human Integrin b3 around the phosphorylation site of tyrosine 773 (P-L-YP-K-E).
SpecificityRecognizes human ITGB3, phosphorylated at Tyr773. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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