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You are here:Home » Antibodies » Antibodies-Integrin » Anti -Integrin beta 7

Anti -Integrin beta 7


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IC FC
Human Integrin beta 7 (also Integrin beta P and M290 IEL Ag) is a 120kD member of the integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704aa extracellular domain (ECD) (aa20-723) and a 52aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa150-389) and four cysteine-rich EGF-like repeats. One splice variant exists that shows a deletion of aa501-648. Integrin beta 7 forms a nondisulfide linked heterodimer with alpha 4 and alpha E integrins. Alpha 4 beta7 binds fibronectin, VCAM-1 and MADCAM1, while alpha E beta7 binds E-cadherin. The ECD of human beta 7 is 87% aa identical to the ECD of mouse beta 7.
Catalog #I7661-45C
ApplicationsSuitable for use in Flow Cytometry, Direct ELISA and Immunocytochemistry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 2.5ug/10e6 cells using human peripheral blood lymphocytes
Immunocytochemistry: 8-25ug/ml using immersion fixed human peripheral blood lymphocytes
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No9H135
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa20-723f rom human Integrin beta 7 expressed in CHO cells. (P26010).
SpecificityRecognizes human Integrin beta 7. Does not recognize recombinant human intergrin b1, b2, b3, b4, b5, b6, b8 or recombinant mouse integrin b4 or b7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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