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You are here:Home » Antibodies » Abs to Integrin » Anti -ITGB7 (Integrin B7, Integrin beta-7, Gut Homing Receptor beta Subunit)

Anti -ITGB7 (Integrin B7, Integrin beta-7, Gut Homing Receptor beta Subunit)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
Integrin B7 is a 130kD glycoprotein, also known as integin Bp. It is a member of the Ig superfamily. In association with integrin a4 or aE chain, B7 forms a4/B7 or aE/B7 heterodimer. a4/B7 (CD49d/B7, LPAM-1) is expressed on majority of peripheral lymphocytes, small subsets of thymocytes and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion, some hematopoietic progenitor cells migration. aE/B7 (CD103/B7,aIEL/B7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/B7 complex is thought to play a role in lymphocyte retention via interaction with its lignd E-Cadherin. This antibody has been reported to react with mouse and human B7 integrin and to block B7 integrin-mediated cell adhesion in in vitro and in vivo studies.
Catalog #I7661-45K
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 0.5ug/10e5 cells in 100ul
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a, k
Clone NoFIB504
HostRat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenTK1 cells
SpecificityRecognizes human Integrin B7. Species Crossreactivity: mouse, chimpanzee, baboon, cynomogus, rhesus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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