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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin beta-like 1 with EGF-like Repeat Domains (ITGBL1)

Anti -Integrin beta-like 1 with EGF-like Repeat Domains (ITGBL1)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified E B IH IC
By screening an EST cDNA database for sequence homology with integrins, Berg et al. (1999) identified overlapping partial-length cDNA clones from human osteoclastoma, fetal lung, and umbilical vein endothelial cDNA libraries. A subsequent screening identified a potential full-length clone from an osteoblast cell cDNA library. The novel cDNA clone was found to encode a 494-amino acid protein, which the authors designated TIED (ten beta-integrin EGF-like repeat domains). The sequence comprised a typical signal peptide, followed by a hydrophilic 471-amino acid domain containing 10 tandem EGF-like repeats strikingly similar to those found in the cysteine-rich 'stalk-like' structure of integrin-beta subunits. Northern blot analysis revealed a single RNA transcript of approximately 2.8 kb. TIED was widely expressed in many tissues, but readily detectable only in aorta.
Catalog #I7661-49
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:250
Immunohistochemistry: 1:100
Immunocytochemistry: 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa242-291 of ITGBL1.
SpecificityRecognizes human ITGBL1 (Integrin beta-like 1 with EGF-like Repeat Domains)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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