Anti -Interferon gamma (IFNg, IFN gamma, IFg, Immune Interferon, IFN Immune, IFI,
Macrophage Activating Factor, MAF, T Cell Interferon, Type II Interferon)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B |
|
| Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN- ), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN- is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN- expression is induced by IL-2, TNF- and IL-12 and suppressed by IL-4, IL-10, and TGF- (2). IFN- binds to IFN- receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN- | | | protects against tumor development and directs immunogenic phenotype (3). IFN- has been implicated various human diseases, such as multiple sclerosis and insulin-dependent | | | diabetes mellitus (4). | | | Catalog # | I7661-68B | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H409 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide, 0.05% BSA. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues human IFN-gamma. | | Specificity | Recognizes human IFN gamma. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
