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You are here:Home » Antibodies » Abs to Interferon » Anti -Interferon gamma (IFNg, IFN gamma, IFg, Immune Interferon, IFN Immune, IFI, Macrophage Activating Factor, MAF, T Cell Interferon, Type II Interferon)

Anti -Interferon gamma (IFNg, IFN gamma, IFg, Immune Interferon, IFN Immune, IFI,
Macrophage Activating Factor, MAF, T Cell Interferon, Type II Interferon)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN- ), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN- is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN- expression is induced by IL-2, TNF- and IL-12 and suppressed by IL-4, IL-10, and TGF- (2). IFN- binds to IFN- receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN-
protects against tumor development and directs immunogenic phenotype (3). IFN- has been implicated various human diseases, such as multiple sclerosis and insulin-dependent
diabetes mellitus (4).
Catalog #I7661-68B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H409
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues human IFN-gamma.
SpecificityRecognizes human IFN gamma.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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