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Interferon alpha 1b, Recombinant, Human (IFNa1b)
Interferon alpha 1b, Recombinant, Human (IFNa1b)
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| Interferon-gamma (IFN- , also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-& or the various IFN- family proteins. Mature IFN- exists as noncovalently-linked homodimers. Human IFN- is highly species specific and is biologically active only in human and primate cells. | | | Catalog # | I7661-71A | | IFN- was originally characterized based on its antiviral activities. The protein also exerts anti-proliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN- induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN- also augments TH1 cell expansion and may be required for TH1 cell differentiation. | | IFN- exerts its biological activities by binding to specific cell surface receptors with high-affinity binding sites. The IFN- receptor is present on almost all cell types except mature erythrocytes and has been cloned and characterized. The IFN- receptor is structurally related to the recently cloned IL-10 receptor. | | Source | E. coli | | Biological Activity | Bioactivity is detected using WISH cell (a heteroploid human amnion cell line) as dependent cell strain. The specific activity shall be not less than 1.5×10e7 IU/mg of protein. | | Endotoxin | 1EU/ug (LAL) | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 1 month at 4 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~17kD | | Source | E. coli | | Purity | 98% as determined by SDS-PAGE and HPLC. | | Form | Supplied as a lyophilized powder from 0.2um sterile-filtered solution in PBS, pH 7.0, 50ug of HSA per 1ug of cytokine. Reconstitute with sterile, dH2O to 0.1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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