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Anti -Interferon alpha Receptor 1, phosphorylated (Ser535/Ser539) (IFNaR1, IFN alpha REC, IFN alpha Receptor, IFN alpha/beta Receptor alpha, IFNAR, Interferon (alpha, beta and omega) Receptor 1)
Anti -Interferon alpha Receptor 1, phosphorylated (Ser535/Ser539) (IFNaR1, IFN alpha REC,
IFN alpha Receptor, IFN alpha/beta Receptor alpha, IFNAR, Interferon (alpha, beta and
omega) Receptor 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1. | | | Catalog # | I7661-76T4 | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000. The molecular weight of IFNAR1 varies with cell line in response to different levels of glycosylation. In 293 and HeLa cells, the mature form is ~110-130kD. | | Immunohistochemistry: 1:1000. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to amino acid residues surrounding the human phospho-Ser 535, 539 type 1 interferon receptor subunit 1 (IFNAR1). Cellular Localization: Type I membrane protein. | | Specificity | Recognizes human Interferon alpha Receptor 1 phosphorylated at Ser535/539. Species crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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