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You are here:Home » Antibodies » Abs to Interferon » Anti -Interferon alpha Receptor 1, phosphorylated (Ser535/Ser539) (IFNaR1, IFN alpha REC, IFN alpha Receptor, IFN alpha/beta Receptor alpha, IFNAR, Interferon (alpha, beta and omega) Receptor 1)

Anti -Interferon alpha Receptor 1, phosphorylated (Ser535/Ser539) (IFNaR1, IFN alpha REC,
IFN alpha Receptor, IFN alpha/beta Receptor alpha, IFNAR, Interferon (alpha, beta and
omega) Receptor 1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
Catalog #I7661-76T4
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000. The molecular weight of IFNAR1 varies with cell line in response to different levels of glycosylation. In 293 and HeLa cells, the mature form is ~110-130kD.
Immunohistochemistry: 1:1000.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding the human phospho-Ser 535, 539 type 1 interferon receptor subunit 1 (IFNAR1). Cellular Localization: Type I membrane protein.
SpecificityRecognizes human Interferon alpha Receptor 1 phosphorylated at Ser535/539. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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