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Interferon alpha A (alpha 2a), Recombinant, Human (IFNaA, IFNa2a)
Interferon alpha A (alpha 2a), Recombinant, Human (IFNaA, IFNa2a)
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| Human Interferon-alpha 2a (IFN-±2a) is a single polypeptide chain of 165 amino acid residues, containing 4 Cys to form two disulfide bonds at positions of Cys1-Cys29 and Cys98-Cys138 and it has a molecular mass of approximately 19kD. | | | Catalog # | I7662-10A3 | | IFN-± can exert certain cell activities through binding to specific cell surface receptors, as firstly induce to develop special proteins, such as protein kinase and 2, 5-oligo polyadenylic acid synthase etc. The unique character of two enzymes is that they can be activated respectively by double chains RNA to produce the effect of self-phosphorylation. IFN can also enhance phagocytosis activity of macrophage and special toxicity of lymphocyte to target cells to cause immunoregulation. | | Its biological effects contains | (1) Anti-virus: IFN-± has broad-spectrum anti-virus effect; (2) Cytostatic effect to certain cells; (3) immunoregulation effect: accelerates the expression of MHC antigen by most cells and active NK cells as well as CTL. (4) Repress and kill tumor cells: IFN-± kills the tumor cells through accelerating the immunological function and enhancing the killing ability of macrophage, NK and CTL. | | | | Source: | | Escherichia coli. | | Biological Activity | Bioactivity is detected using cytopathic effect inhibition assay method, WISH cell (a heteroploid human amnion cell line) as dependent cell strain. The specific activity shall be not less than 1.0×10e8 IU/mg. | | Endotoxin | 1EU/ug (LAL) | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 1 month at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~19.2kD | | Source | E. coli | | Purity | 97% as determined by SDS-PAGE and HPLC. | | Form | Supplied as a lyophilized powder from 0.2um sterile-filtered solution in PBS, pH 7.0, 50ug of HSA per 1ug of cytokine. Reconstitute with sterile, dH2O to 0.1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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