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You are here:Home » Antibodies » Abs to Interferon » Anti -IFN gamma (IFNg, IFNG, Interferon gamma)

Anti -IFN gamma (IFNg, IFNG, Interferon gamma)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFNy), a sole member of the Type II IFN family, is involved in lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFNy is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFNy expression is induced by IL-2, TNF-a and IL-12 and suppressed by IL-4, IL-10, and TGF-b (2). IFNy binds to IFNy receptor (IFNGR), which stimulates various immuno-responses such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFNy protects against tumor development and directs immunogenic phenotype (3). IFN y has been implicated in various human diseases, such as multiple sclerosis and insulin-dependent diabetes mellitus (4).
Catalog #I7662-18T
ApplicationsSuitable for use in Immunocytochemistry and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: 1:50-1:100
Immunocytochemistry: 1:250-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR1108
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human IFN gamma.
SpecificityRecognizes human IFN gamma (IFNG). Species crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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