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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified E

Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
Catalog #	I7662-18X
Applications	Suitable for use in ELISA. Other applications not tested.
Recommended Dilutions	ELISA (Detection): 0.1-1ug/ml. Dilutions should be made in a buffer appropriate for use in ELISA, such as PBS supplemented with 0.5% BSA, 0.1% Tween-20.
	Optimal dilutions to be determined by the researcher.
Hybridoma	Balb/c (Charles River) / Sp2/O Ag14
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	2B2.115
Host	Mouse
Source	Porcine
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. Labeled with Biotin.
Purity	Purified
Immunogen	Recombinant porcine IFN-g
Specificity	Recognizes natural and recombinant porcine IFN-g.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.