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Anti -IRF1 (Interferon Regulatory Factor 1, IRF-1, MAR)
Anti -IRF1 (Interferon Regulatory Factor 1, IRF-1, MAR)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
|
| IRF1(interferon regulatory factor1) is a 45kD member of the IRF family of proteins. It is induced by TLR9 and INF stimulation, and positively regulates theexpression of IFNb NOS and1L12p35. | | | Human IRF1 is 325aa in length. It contains an Nterminal DNA binding basic region (aa1140) | | | and an acidic Cterminus(aa147-325). Lys275 and 299 can be SUMOylated, which blocks activity, or ubiquinated at Lys299, which initiates degradation. There is a splice variant that shows an 11aa substitution for the C terminal 86aa. Over aa171-325,human IRF1 shares 83% aa identity with both canine and porcine IRF1. | | | Catalog # | I7662-81G | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | Not determined | | Form | Supplied as a lyophilized powder in PBS with Trehalose. Reconstitute with sterile PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to Thr147Pro325 in human IRF1 expressed in E. coli (P10914). | | Specificity | Recognizes human IRF1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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