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You are here:Home » Antibodies » Abs to Interferon » Anti -IRF1 (Interferon Regulatory Factor 1, IRF-1, MAR)

Anti -IRF1 (Interferon Regulatory Factor 1, IRF-1, MAR)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
IRF1(interferon regulatory factor1) is a 45kD member of the IRF family of proteins. It is induced by TLR9 and INF stimulation, and positively regulates theexpression of IFNb NOS and1L12p35.
Human IRF1 is 325aa in length. It contains an Nterminal DNA binding basic region (aa1140)
and an acidic Cterminus(aa147-325). Lys275 and 299 can be SUMOylated, which blocks activity, or ubiquinated at Lys299, which initiates degradation. There is a splice variant that shows an 11aa substitution for the C terminal 86aa. Over aa171-325,human IRF1 shares 83% aa identity with both canine and porcine IRF1.
Catalog #I7662-81G
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS with Trehalose. Reconstitute with sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to Thr147Pro325 in human IRF1 expressed in E. coli (P10914).
SpecificityRecognizes human IRF1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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