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You are here:Home » Antibodies » Abs to Interferon » Anti -Interferon Regulatory Factor 3 (IRF3, IRF-3)

Anti -Interferon Regulatory Factor 3 (IRF3, IRF-3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes.
Catalog #I7662-86K
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:2,000-1:3,000
Optimal dilutions to be determined by the researcher.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10D320
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human IRF3 (aa108-166) purified from E. coli.
SpecificityRecognizes human interferon regulatory factor 3 (IRF3), a 55kDa constitutively expressed member of the IRF family, which acts as vital regulator of gene expression in innate immunity.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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