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You are here:Home » Antibodies » Abs to Interferon » Anti -Interferon Regulatory Factor 7 (IRF7)

Anti -Interferon Regulatory Factor 7 (IRF7)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IF
IRF7 is highly induced in response to IFN but remains inactive until phosphorylated in response to viral infection (1-3). Once phosphorylated, IRF7 binds critical promoter elements regulating IFNa gene expression and is absolutely required for expression of a subset of IFNa genes comprising a second wave of IFN production following virus infection (2). IRF7 may also play a role in IFNb gene expression as part of a complex with IRF3 (4).
Catalog #I7662-90
ApplicationsSuitable for use in Immunofluorescence, Gel Mobiility Shift Assay, ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsImmunofluorescence: ~10ug/ml
Gel Mobiility Shift Assay: 0.2-1ug / 5ul reaction
ELISA: 0.1-1ug/ml
Western Blot: 0.5-2ug/ml
Immunoprecipitation: 3-5ug/extract from 10e7 cells
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlMouse IRF7 transfected 293T cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant protein derived from aa207-452 of the murine IRF7 protein.
SpecificityRecognizes mouse IRF7 protein. Does not crossreact with other IRF proteins. Reactivity with endogenous protein has not been observed.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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