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You are here:Home » Antibodies » Abs to Interferon » Anti -Interferon Regulatory Factor 9 (IRF9, IFN-alpha-responsive transcription factor subunit, Interferon-stimulated gene factor 3 gamma, ISGF3, ISGF3G, ISGF-3 gamma, ISGF3 p48 subunit, p48, Transcriptional regulator ISGF3 subunit gamma)

Anti -Interferon Regulatory Factor 9 (IRF9, IFN-alpha-responsive transcription factor
subunit, Interferon-stimulated gene factor 3 gamma, ISGF3, ISGF3G, ISGF-3 gamma, ISGF3 p48
subunit, p48, Transcriptional regulator ISGF3 subunit gamma)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B
IRF9 (interferon regulatory factor 9; also ISGF3- ) is a 48kD member of the IRF family
of proteins. It is widely expressed, and serves as a component of the ISGF3 complex. Following activation of IFNAR by IFN- / , IRF9 is acetylated by CBP on Lys81. IRF9 then associates with activated STAT1 and STAT2 to form an ISGF3 complex that is translocated into the nucleus. Human IRF9 is 393 amino acids (aa) in length. It contains an N-terminal DNA-binding region (aa 11-112) that contains an NLS (aa 66-85), plus a STAT-binding domain (aa 200-393). There are two potential isoform variants. One shows a deletion of aa 218-331 and 340-393, while another shows a five aa substitution for aa 217-393. Over aa 238-393, human IRF9 shares 79% aa identity with mouse IRF9.
Catalog #I7662-93M
ApplicationsSuitable for Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
StorageLyophilized samples are stable for twelve months from date of receipt when stored at -20°C to -70°C. Upon reconstitution, the antibody can be stored at 2°-8°C for 1 month without detectable loss of activity. Reconstituted antibody can also be aliquotted and stored frozen at -20°C to -70°C in a manual defrost freezer for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationAs reported
FormLyophilized from a 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute in PBS containing 0.02% sodium azide.
PurityPurified by isolating the IgG fraction.
ImmunogenE. coli-derived rhIRF9 (aa 238-393).
SpecificityDetects endogenous human and mouse IRF9 in Western blot with an approximate molecular weight of 35kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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