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You are here:Home » Antibodies » Abs to Interleukin » Anti -Interleukin 1 alpha (IL-1a)

Anti -Interleukin 1 alpha (IL-1a)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
IL-1alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.
Catalog #I7663-02F1
ApplicationsSuitable for use in ELISA as a capture antibody. Other applications not tested.
Recommended DilutionELISA: 1-5ug/ml in coating buffer immediately prior to use, and coat each well with 100ul. Further dilutions may be made in medium or buffered solution with carrier protein, such as PBS with 0.1-1% BSA.
Optimal dilutions to be determined by the researcher.
HybridomaNSO myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No4A6
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.5. No preservative added. Also available with azide. See I7663-02F.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant human IL-1a.
SpecificityRecognizes natural and recombinant human IL-1a.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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