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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL1A (Interleukin-1 alpha, IL-1 alpha, Hematopoietin-1, IL1F1)

Anti -IL1A (Interleukin-1 alpha, IL-1 alpha, Hematopoietin-1, IL1F1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Interleukin 1 alpha is synthesized as a 31kD promolecule that does not contain a signal sequence. Following proteolytic cleavage, the mature 17kD molecule is released as a result of cell injury or apoptosis. IL-1 alpha stimulates bone osteoclast activity, has a role in the modulation of extracellular fluid calcium homeostasis and apoptosis, activates T and B lymphocytes and NK cells, and functions in development. Movement of the IL-1 alpha promolecule to the nucleus in response to endotoxin where it augments transcription of proinflammatory genes has also been documented.
Catalog #I7663-03M
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:400
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 0.03% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to human IL1A expressed in E. coli strain BL21 (DE3).
SpecificityRecognizes human IL1A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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