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Specifications

Clone Host Grade Applications Polyclonal Chicken Affinity Purified E B

Interleukin 1b is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL-1b and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Catalog #	I7663-11F
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	ELISA: 0.2ug/ml
	Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies	I1906 IgY, Chicken Pab Rb x Ch
	I1906-10 IgY, Chicken-HRP Rb x Ch
	I1906-12 IgY, Chicken-FITC Rb x Ch
	I1906-14 IgY, Chicken-AP Rb x Ch
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgY
Host	Chicken
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to aa118-269 of human IL-1b
Specificity	Recognizes human IL-1b.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.