Anti -Interleukin 1, Family Member 6 (IL-1F6, FIL1e) (PE)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Purified |
FC |
|
| Human interleukin 1 family member number 6 [IL-1F6; also FIL-1 (epsilon)] is a recently discovered member of the IL-1 family of proteins. 1-3 IL-1 family members include IL-1 , IL-1a, IL-1ra, IL-18 and IL-1F5 through F10. 4 All family members show a 12 -strand, -trefoil configuration, and all family members are believed to have arisen from a common ancestral gene that has undergone multiple duplications. 4 IL-1F9 is synthesized as a 158 amino acid (aa) protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site(s). 1-3 It appears to be actively secreted. 1 When found in cell lysate, it presents as an 18 kD monomer. 2 Human to mouse, full length IL-1F6 has 54% aa identity. Within the family, IL-1F6 is 30% aa identical to IL-1ra, and 27%, 31%, 36%, 46%, 57% and 28% aa identical to IL-1 , IL-1F5, F7, F8, F9 and F10, respectively. Cells reported to express IL-1F6 include monocytes, B cells and T cells. 1,4 Notably, IL-1F6 is the only novel IL-1 family member found to be expressed on T-cells. The receptor for IL-1F6 is reported to be a combination of IL-1 Rrp2 and IL-1RacP. 5 Recombinant IL-1F6, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NF- B and MAPK in an IL- 1 Rrp2 dependent manner. This suggests that IL-1F6 may signal in similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex. | | | Catalog # | I7663-24R1 | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 7H12 | | Host | Rat | | Source | Mouse | | Concentration | As reported | | Form | Supplied as a liquid in PBS, BSA. Conjugated to PE. | | Purity | Purified immunoglobulin | | Immunogen | Mouse IL-1F6/FIL1e | | Specificity | Recognizes mouse IL-1F6/FIL1e. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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