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You are here:Home » Antibodies » Antibodies-Interleukin » Anti -Interleukin 1 Receptor AcP, C1 (Interleukin-1 Receptor Accessory Protein, IL-1 Receptor Accessory Protein, IL-1RAcP, IL1RAP, C3orf13, FLJ37788, Interleukin-1 Receptor 3, IL1R3, IL-1R3, IL-1R-3)

Anti -Interleukin 1 Receptor AcP, C1 (Interleukin-1 Receptor Accessory Protein, IL-1
Receptor Accessory Protein, IL-1RAcP, IL1RAP, C3orf13, FLJ37788, Interleukin-1 Receptor 3,
IL1R3, IL-1R3, IL-1R-3)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IC IF
The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kB inducing kinae (NIK) and of NF-kB, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
Catalog #I7663-25Y
ApplicationsSuitable for use in ELISA, Western Blot and Immunofluorescence and Immunocytochemistry. Other applications not tested.
Recommended DilutionsELISA: 1:100-1:2000
Western Blot: 1:100-1:2000
Immunofluorescence (IC): 1:10-1:2000
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa whole cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide
PurityPurified by affinity chromatography
ImmunogenSynthetic peptide corresponding to amino acidds near the carboxy terminal of human IL-1RAcP. (NP_608273).
SpecificityRecognizes human IL-1RAcP (C1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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