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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 2, Recombinant, Human (Interleukin-2, IL-2, IL2, Aldesleukin, Lymphokine, T-cell Growth Factor, TCGF)

Interleukin 2, Recombinant, Human (Interleukin-2, IL-2, IL2, Aldesleukin, Lymphokine,
T-cell Growth Factor, TCGF)

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Specifications

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes.
Catalog #I7663-28A1
Recombinant Human IL-2 is a single non-glycosylated mutein (variant form) of human IL-2 polypeptide chain containing 134aa and having a molecular weight of 15.5kD. The sequence of the first five N-terminal aa was determined to be Met-Ala-Pro-Thr-Ser. Recombinant Human IL-2 has a Ser substitute for Cysteine at position 126. Molecular Weight ~15.5kD
ActivityThe ED50 as determined by the dose-dependent stimulation of mouse CTLL-2 cells is less than 0.0645ng/ml, corresponding to a specific activity of 16.9MIU/mg.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Stable for at least 6 months at -20°C. Reconstitute with sterile deionized water to a concentration 100ug/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~15.5kD
SourceE. coli
Purity98% (RP-HPLC, SDS-PAGE).
FormSupplied as a lyophilized powder in PBS, pH 7.5. No preservative added. Reconstitute with 20mM acetic acid to a concentration 100ug/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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