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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 33, Recombinant, Human (IL-33)

Interleukin 33, Recombinant, Human (IL-33)

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Specifications

Interleukin 33 (IL-33) is a 32kD proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kD and C-terminal fragment of 18kD by cleavage of caspase-1. Recombinant human IL-33(C-terminal fragment) was expressed in E. coli and purified by using conventional chromatography techniques.
Molecular Weight: 18kD (160 amino acids)
Catalog #I7663-97
Sequences
MSITGISPIT/ EYLASLSTYN/ DQSITFALED/ ESYEIYVEDL/ KKDEKKDKVL/ LSYYESQHPS/ NESGDGVDGK/ MLMVTLSPTK/ DFWLHANNKE/ HSVELHKCEK/ PLPDQAFFVL/ HNMHSNCVSF/ ECKTDPGVFI/ GVKDNHLALI/ KVDSSENLCT/ ENILFKLSET
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight18 kD
SourceRecombinant, Human expressed in E. coli
Purity95% by SDS PAGE
Concentration~1mg/ml
FormSupplied as a liquid in 20mM Tris, pH 8.0
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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