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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL33 (IL1F11, Interleukin-33, IL-33, Interleukin-1 Family Member 11, IL-1F11, Nuclear Factor from High Endothelial Venules, NF-HEV, C9orf26, NFHEV) (PE)

Anti -IL33 (IL1F11, Interleukin-33, IL-33, Interleukin-1 Family Member 11, IL-1F11,
Nuclear Factor from High Endothelial Venules, NF-HEV, C9orf26, NFHEV) (PE)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
Interleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a member of IL-1 cytokine family. IL-33 is constitutively expressed in smooth muscle and airway epithelia and is up-regulated by IL-1a or IL-1b in arterial smooth muscle, dermal fibroblasts, and keratinocytes. IL-33 is synthesized as a 270aa, 32kD proform that localizes to the nucleus and may regulate gene transcription. Cleavage generates mature IL-33 as an 18kD C-terminal pro-inflammatory fragment which binds IL-1 R4/ST2 on Th2 and mast cells. Mature human IL-33 shares 55% aa identity with mouse IL-33.
Catalog #I7663-97S
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: Intracellular expression of I7663-97S is determined by using 488nm wavelength excitation and monitoring emitted fluorscence with a detector optimized to collect peak emissions at 565-605nm.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No12K111
HostRat
SourceHuman
Concentration~0.025mg/ml
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa112-270 from human IL-33, expressed in E.coli (Accession# O95760).
SpecificityRecognizes human IL-33.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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