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Anti -IL33 (IL1F11, Interleukin-33, IL-33, Interleukin-1 Family Member 11, IL-1F11, Nuclear Factor from High Endothelial Venules, NF-HEV, C9orf26, NFHEV) (APC)
Anti -IL33 (IL1F11, Interleukin-33, IL-33, Interleukin-1 Family Member 11, IL-1F11,
Nuclear Factor from High Endothelial Venules, NF-HEV, C9orf26, NFHEV) (APC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
FC |
|
| Interleukin-33, also known as NF-HEV and DVS 27, is a member of IL-1 cytokine family. IL-33 is constitutively expressed in smooth muscle and airway epithelia and is up-regulated by IL-1A or IL-1B in arterial smooth muscle, dermal fibroblasts, and keratinocytes. IL-33 is synthesized as a 270aa, 32kD proform that localizes to the nucleus and may regulate gene transcription. Cleavage generates mature IL-33 as an 18kD C-terminal pro-inflammatory fragment which binds IL-1 R4/ST2 on Th2 and mast cells. Mature human IL-33 shares 55% aa identity with mouse IL-33. | | | Catalog # | I7663-97T | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Excitation | 620-650nm | | Emission | 660-670nm | | Storage and Stability | May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2B | | Clone No | 12K111 | | Host | Rat | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC). | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant corresponding to aa112-270 from human IL-33 expressed in E.coli. | | Specificity | Recognizes human IL-33. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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