Interleukin 4, Recombinant, Mouse (IL-4, B Cell Stimulatory Factor 1, BSF1, Binetrakin,
HCGF, Hodgkin's Cell Growth Factor, IA Inducing Factor, Lymphocyte Stimulatory Factor 1,
Macrophage Fusion Factor, Mast Cell Growth Factor 2, MCGF2, MFF, MGC79402, Pit
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| Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5kD globular protein containing 120 amino acid residues. | | | Catalog # | I8426-10 | | AA Sequence | MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S | | Biological Activity | Fully biologically active when compared to standards. The ED50 was determined by the dose-dependent proliferation of murine HT-2 cells is < 2ng/ml, corresponding to a specific activity of > 5 x 105 units/mg. | | Responding Cells (partial list) | B cells and certain T cells | | Concentration Range for most in vitro applications | 0.5-5ng/ml | | Storage and Stability | Lyophilized powder is stable for at least 12 months at -20°C Reconstituted product must be stored in working aliquots at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Molecular Weight | 13.5kD | | Source | Murine, recombinant protein expressed in E. coli | | Purity | 98% by SDS-PAGE analyses. | | Endotoxin | 0.1ng/ug (1EU/ug). | | Form | Supplied as a lophilized protein without additives. | | Reconstitution | Reconstitute in water to a concentration of 1mg/ml. This solution can then be diluted into other aqueous buffers. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Interleukin 4, Recombinant, Mouse (IL-4, B Cell Stimulatory Factor 1, BSF1, Binetrakin, HCGF, Hodgkin's Cell Growth Factor, IA Inducing Factor, Lymphocyte Stimulatory Factor 1, Macrophage Fusion Factor, Mast Cell Growth Factor 2, MCGF2, MFF, MGC79402, Pit |
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