Interleukin 4 Induced Protein 1, Recombinant, Human (IL4I1, FIG1, L-amino acid oxidase)
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| Interleukin 4 induced protein 1(IL4I1), also known as protein FIG1 and Lamino acid oxidase, is encoded by a Bcell IL4inducible gene, FIG1, and is highly expressed in primary metastinal Bcell lymphomas (14). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL4I1 has Lamino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hI L4I1 inhibited the proliferation of CD3stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5) . Its inhibitory effect was dependent on enzymatic activity and H2O2 production. Its restricted expression to l ymphoid tissues indicates that it may play an important function in the immune system (1, 4). | | | Catalog # | I8426-48 | | Source | Chinese Hamster Ovary cell line, CHO-derived Gln22 Ser567, with a C-terminal 6 His tag, Accession #Q96RQ9 | | Predicted Molecular Mass | 61kD, SDS-PAGE: 70-75kD | | Activity | Measured by its ability to oxidize phenylalanine in a horseradish peroxidase coupled | | assay. The specific activity is 300pmol/min/ug, as measured under the described conditions. | | Endotoxin | 1.0 EU per 1ug of the protein by the LAL method. | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | 12 months from date of receipt, 20 to 70°C as supplied. | | 1 month, 2 to 8°C under sterile conditions after reconstitution. | | months, 20 to 70°C under sterile conditions after reconstitution. | | Avoid repeated freeze thaw cycles. | | Purity | 95% by SDSPAGE under reducing conditions and visualized by silver stain. | | Concentration | As reported | | Form | Lyophilized from a 0.2um filtered solution in PBS, Tris, sodium chloride and glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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