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You are here:Home » Molecular Biology » MB-Growth Factors-Interleukin » Interleukin 4 Induced Protein 1, Recombinant, Human (IL­4I1, FIG­1, L-amino acid oxidase)

Interleukin 4 Induced Protein 1, Recombinant, Human (IL­4I1, FIG­1, L-amino acid oxidase)


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Interleukin 4 induced protein 1(IL4I1), also known as protein FIG­1 and L­amino acid oxidase, is encoded by a B­cell IL4­inducible gene, FIG1, and is highly expressed in primary metastinal B­cell lymphomas (1­4). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL4I1 has L­amino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hI L4I1 inhibited the proliferation of CD3­stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5) . Its inhibitory effect was dependent on enzymatic activity and H2O2 production. Its restricted expression to l ymphoid tissues indicates that it may play an important function in the immune system (1, 4).
Catalog #I8426-48
Chinese Hamster Ovary cell line, CHO-derived Gln22 Ser567, with a C-terminal 6 His tag, Accession #Q96RQ9
Molecular Weight61kD, SDS-PAGE: 70-75kD
ActivityMeasured by its ability to oxidize phenylalanine in a horseradish peroxidase coupled assay. The specific activity is 150pmol/min/ug, as measured under the described conditions.
Storage and StabilityStore at -70°C. Aliquot to avoid repeated freezing and thawing. Stable for 6 months after receipt at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight61kD
Purity95% by SDS­PAGE under reducing conditions and visualized by silver stain.
ConcentrationAs reported
FormLyophilized from a 0.2um filtered solution in PBS, Tris, sodium chloride and glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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