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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 5, Recombinant, Human (IL-5, BCDF-alpha, Eosinophil Differentiation Factor, EDF)

Interleukin 5, Recombinant, Human (IL-5, BCDF-alpha, Eosinophil Differentiation Factor,
EDF)

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Specifications

Interleukin-5 (IL-5) is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils.Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26kD disulfide-linked homodimeric protein containing two 116 amino acid chains.
Catalog #I8427
Biological Activity Human IL-5 is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent proliferation of TF-1 cells is 0.15ng/ml, corresponding to a specific activity of 6x10e6 units/mg. For most in vitro applications, IL-5 exerts its biological activity in the concentration range of 0.1-10ng/ml.
Responding Cells (partial list) B cells, eosinophils
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile dH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at
-20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of Origin USA
Molecular Weight26.2kD
SourceHuman, recombinant protein expressed in E. coli
PurityHighly Purified ( 98% by SDS-PAGE)
Endotoxin0.1ng/ug
FormSupplied as a lyophilized powder without additives.
ReconstitutionReconstitute with sterile water to a concentration of 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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