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Interleukin 5, Recombinant, Human (IL-5, BCDF-alpha, Eosinophil Differentiation Factor, EDF)
Interleukin 5, Recombinant, Human (IL-5, BCDF-alpha, Eosinophil Differentiation Factor,
EDF)
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| Interleukin-5 (IL-5) is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils.Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26kD disulfide-linked homodimeric protein containing two 116 amino acid chains. | | | Catalog # | I8427 | | Biological Activity | Human IL-5 is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent proliferation of TF-1 cells is 0.15ng/ml, corresponding to a specific activity of 6x10e6 units/mg. For most in vitro applications, IL-5 exerts its biological activity in the concentration range of 0.1-10ng/ml. | | Responding Cells (partial list) | B cells, eosinophils | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile dH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at | | -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Country of Origin | USA | | Molecular Weight | 26.2kD | | Source | Human, recombinant protein expressed in E. coli | | Purity | Highly Purified ( 98% by SDS-PAGE) | | Endotoxin | 0.1ng/ug | | Form | Supplied as a lyophilized powder without additives. | | Reconstitution | Reconstitute with sterile water to a concentration of 0.1-1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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