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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 6, Recombinant, Human (IL-6)

Interleukin 6, Recombinant, Human (IL-6)

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Specifications

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Ra and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9kD protein containing 184aa residues.
Catalog #I8428
Biological Activity Fully biologically active when compared to standards. The ED50 was determined by the dose dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is 0.1ng/ml, corresponding to a specific activity of 1x10e7units/mg.
Amino Acid SequencePVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight20.9kD
SourceE. coli
Purity98% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug.
FormSupplied as a lyophilized powder. Reconstitute with sterile ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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