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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 6 Receptor, Recombinant, Human (IL-6R)

Interleukin 6 Receptor, Recombinant, Human (IL-6R)

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Specifications

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6kD protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).
Catalog #I8428-39J
Storage and Stability Lyophilized powder may be stored at -20°C. Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity 98% by SDS-PAGE and HPLC analyses
Endotoxin 0.1ng/ug (1EU/ug)
Reconstitution Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml.
Biological Activity The ED50 as determined by itsí ability to intensify the IL-6 induced growth inhibition of murine M1 cells is < 5.0 ng/ml, in the presence of 20ng/ml of
rhIL -6.
AA Sequence  LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH ASGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPAPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQD
Country of Origin USA
SourceHEK 293 cells
FormSupplied as a lyophilized powder from
PBS, pH 7.2.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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