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Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)
Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)
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| Interleukin-10 (IL 10) is also known as human cytokine synthesis inhibitory factor (CSIF) and inhibits the synthesis of pro-inflammatory cytokines like IFN-gamma, IL2, IL3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. This protein has effects in immunoregulation and inflammation and down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. Recombinant IL10 protein, fused to His-tag at N-terminus, was expressed in E. coli and was purified by conventional chromatography techniques. | | | Catalog # | I8432-01T | | Source | Human, His-tagged, Recombinant, E. coli, 19-178aa | | AA Sequence | MGSSHHHHHH SSGLVPRGSH MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N | | Endotoxin Level | 1.0 EU/1ug (LAL). | | Storage and Stability | Storage and Stability: | | For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 20.94kD | | Source | E. coli | | Purity | Purified 95% by SDS-PAGE. | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in 20mm Tris-HCl buffer, pH 8.0, 20% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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