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You are here:Home » Antibodies » Abs to Interleukin » Anti -Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

Anti -Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E B FC
Interleukin-10 (IL-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 18.7kD protein that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI. The reported biological activities of IL-10, which may be inter-related, include inhibition of macrophage mediated cytokine synthesis, suppression of the delayed type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production.
Catalog #I8432-02G
ApplicationsSuitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1:10-1:100; 10ul labels 10e6 cells in 100ul. Membrane permeabilization is required.
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlBreast Carcinoma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No10B2358
HostRat
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenT cell derived mouse IL10.
SpecificityRecognizes mouse Interleukin 10. This immunoregulatory cytokine is expressed by (B-1) B cells that express CD5 (Ly-1) and a subset of lectin stimulated T cells. Reported to neutralize IL-10 (see ref 3)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMGC126450, MGC126451, TGIF


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