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Anti -Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)
Anti -Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. | | | Catalog # | I8432-11E | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 8L466 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | As reported | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Ni-NTA purified recombinant human IL-10 expressed in E. Coli strain BL21 (DE3). | | Specificity | Species Crossreactivity: Human. Other species have not been tested | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | MGC126450, MGC126451, TGIF |
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