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You are here:Home » Antibodies » Antibodies-Interleukin » Anti -Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

Anti -Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)


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Clone Host Grade Applications
Monoclonal Rat Affinity Purified E IP
Mouse interleukin 10 (IL-10) is a multifunctional 30-40kD cytokine which is produced by TH2 mouse T Helper cell clones and which inhibits the synthesis of several cytokines by TH1 cells. Interleukin 10 was for this reason originally known as the Cytokine Synthesis Inhibitory Factor (CSIF). Interleukin 10 has activities which involve a wide variety of cell types. These activities include inhibition of macrophage cytokine synthesis; inhibition of antigen presentation (selective for TH1 cells); enhancement of B-cell survival; enhancement of MHC class II expression; contribution to the overall function of TH2 cells. Mouse IL-10 has been shown to exhibit extensive sequence similarity to human IL-10 and to an open reading frame in the Epstein-Barr virus genome BLRF-1. In contrast to human IL-10 which is active on mouse cells, mouse IL-10 is not active in human cells. Given the aforementioned range of effects of IL-10 and its potential anti-inflammatory properties, antibodies capable of blocking the biological activity are clearly essential in the study of these effects.
Catalog #I8432-24E
ApplicationsSuitable for use in Neutralization, ELISA and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone NoJES5-2A5
ConcentrationNot determined.
FormSupplied as a lyophilized powder. Reconstitute with 1ml ddH2O.
PurityPurified by Protein G affinity chromatography.
ImmunogenMouse IL-10.
SpecificityRecognizes mouse IL 10 at ~30-40kD. Species sequence homology: human. In contrast to human IL 10 which is active on murine cells, murine IL 10 is not active in human cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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