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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL12A (NK Cell Stimulatory Factor Chain 1, NKSF1, Cytotoxic Lymphocyte Maturation Factor 35kD Subunit, CLMF p35, IL-12 Subunit p35, Interleukin-12 Subunit alpha, IL-12A)

Anti -IL12A (NK Cell Stimulatory Factor Chain 1, NKSF1, Cytotoxic Lymphocyte Maturation
Factor 35kD Subunit, CLMF p35, IL-12 Subunit p35, Interleukin-12 Subunit alpha, IL-12A)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Interleukin 12A is a novel signaling cytokine belonging to the Interleukin-6 protein superfamily. Interleukin-12 alpha chain precursor (IL-12A) is a 35kD subunit of disulfide-linked heterodimer of cytokine IL-12 and has a broad array of biological activities. Reports suggest that Interleukin 12A can act as a growth factor for activated T and NK cells and enhance the lytic activity of NK:lymphokine-activated Killer cells. It stimulates the production of IFN-gamma by resting PBMC as well as T-cell-independent induction of interferon (IFN)-gamma, and helps in the differentiation of both Th1 and Th2 cells. It is also involved in positive regulation of tyrosine phosphorylation of Stat4 protein. The signaling process of IL-12A in innate immunity requires nitric oxide synthase 2A. Along with EBI3 it forms a novel heterodimeric cytokine, designated as interleukin-35 (IL-35), that may be specifically produced by T reg cells and is required for maximal suppressive activity.
Catalog #I8434-29J
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlIL-35 recombinant protein lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa200-250 of p35/IL-12A.
SpecificityRecognizes human IL12A. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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