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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 13, Recombinant, Human (IL-13)

Interleukin 13, Recombinant, Human (IL-13)

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Specifications

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1b, TNF-a, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant human IL-13 is a 12.5kD protein consisting of 114 amino acid residues.
Catalog #I8435-10
Endotoxin 1ng/ug (1EU/mg)
Biological ActivityThe ED50 as determined by the dose-dependent proliferation of TF-1 cells was 1ng/ml, corresponding to a specific activity of 1x10e6u/mg.
Amino Acid SequenceSPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GRFN
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight12.5kD
SourceE. coli
Purity98% by SDS-PAGE and HPLC
FormSupplied as a lyophilized powder. Reconstitute with sterile, ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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